Article
PKA phosphorylation couples hepatic inositol-requiring enzyme 1alpha to glucagon signaling in glucose metabolism.
Proceedings of the National Academy of Sciences of the United States of America - 20 Sept 2011
Mao Ting, Shao Mengle, Qiu Yifu, Huang Jialiang, Zhang Yongliang, Song Bo, Wang Qiong, Jiang Lei, Liu Yi, Han Jing-Dong J, Cao Pengrong, Li Jia, Gao Xiang, Rui Liangyou, Qi Ling, Li Wenjun, Liu Yong
Abstract excerpt
The endoplasmic reticulum (ER)-resident protein kinase/endoribonuclease inositol-requiring enzyme 1 (IRE1) is activated through transautophosphorylation in response to protein folding overload in the ER lumen and maintains ER homeostasis by triggering a key branch of the unfolded protein response. Here we show that mammalian IRE1α in liver cells is also phosphorylated by a kinase other than itself in response to...
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