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Article

AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation.

Genes & development - 1 Oct 2020

Van Nostrand Jeanine L, Hellberg Kristina, Luo En-Ching, Van Nostrand Eric L, Dayn Alina, Yu Jingting, Shokhirev Maxim N, Dayn Yelena, Yeo Gene W, Shaw Reuben J

Abstract excerpt

Despite being the frontline therapy for type 2 diabetes, the mechanisms of action of the biguanide drug metformin are still being discovered. In particular, the detailed molecular interplays between the AMPK and the mTORC1 pathway in the hepatic benefits of metformin are still ill defined. Metformin-dependent activation of AMPK classically inhibits mTORC1 via TSC/RHEB, but several lines of evidence suggest...

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Identifiers

PMID: 32912901
DOI: 10.1101/gad.339895.120
PMCID: PMC7528705

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