Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phosphorylation at Ser724 of the ER stress sensor IRE1α governs its activation state and limits ER stress-induced hepatosteatosis.

The Journal of biological chemistry - 1 Jun 2022

Li Yang, Huang Shijia, Wang Jingsi, Dai Jianli, Cai Jie, Yan Shuai, Huang Zhiliang, He Shengqi, Wang Ping, Liu Jianmiao, Liu Yong

Abstract excerpt

Inositol-requiring enzyme 1 (IRE1) is an evolutionarily conserved sensor of endoplasmic reticulum (ER) stress and mediates a key branch of the unfolded protein response in eukaryotic cells. It is an ER-resident transmembrane protein that possesses Ser/Thr protein kinase and endoribonuclease (RNase) activities in its cytoplasmic region. IRE1 is activated through dimerization/oligomerization and autophosphorylation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endoplasmic Reticulum Stress
Share to Endoribonucleases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzyme Activation

Share to Fatty Liver

Share to Fibroblasts

Share to Phosphorylation

Share to Protein Serine-Threonine Kinases

Share to X-Box Binding Protein 1

Source

Open in PubMed Open full text

Identifiers

PMID: 35500653
DOI: 10.1016/j.jbc.2022.101997
PMCID: PMC9144033

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phosphorylation at Ser724 of the ER stress sensor IRE1α governs its activation state and limits ER stress-induced hepatosteatosis.PMID 35500653Read ↗

PKA phosphorylation couples hepatic inositol-requiring enzyme 1alpha to glucagon signaling in glucose metabolism.Semantic proximity Read ↗

Optogenetic Clustering of Human IRE1 Reveals Differential Regulation of Transcription and mRNA Splice Isoform Abundance by the UPRSemantic proximity Read ↗

Pharmacological Inhibition of Inositol-Requiring Enzyme 1α RNase Activity Protects Pancreatic Beta Cell and Improves Diabetic Condition in Insulin Mutation-Induced Diabetes.Semantic proximity Read ↗

A conserved structural determinant located at the interdomain region of mammalian inositol-requiring enzyme 1alpha.Semantic proximity Read ↗

Genetic knock-in of EIF2AK3 variants reveals differences in PERK activity in mouse liver and pancreas under endoplasmic reticulum stress.Semantic proximity Read ↗

The unfolded protein response transducer IRE1α prevents ER stress‐induced hepatic steatosisSemantic proximity Read ↗

Involvement of the IRE1α-XBP1 Pathway and XBP1s-Dependent Transcriptional Reprogramming in Metabolic DiseasesSemantic proximity Read ↗

AMPK leads to phosphorylation of the transcription factor Nrf2, tuning transactivation of selected target genesSemantic proximity Read ↗

Regulation of ERK2 activity by dynamic <i>S</i> -acylationSemantic proximity Read ↗

UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.Semantic proximity Read ↗

Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus.Semantic proximity Read ↗

A topology-dependent IRE1α signaling axis generates a cryptic XBP1 isoform present in human cancersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.