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Article

AMPK Profiling in Rodent and Human Pancreatic Beta-Cells under Nutrient-Rich Metabolic Stress.

International journal of molecular sciences - 1 Jun 2020

Brun Thierry, Jiménez-Sánchez Cecilia, Madsen Jesper Grud Skat, Hadadi Noushin, Duhamel Dominique, Bartley Clarissa, Oberhauser Lucie, Trajkovski Mirko, Mandrup Susanne, Maechler Pierre

Abstract excerpt

Chronic exposure of pancreatic β-cells to elevated nutrient levels impairs their function and potentially induces apoptosis. Like in other cell types, AMPK is activated in β-cells under conditions of nutrient deprivation, while little is known on AMPK responses to metabolic stresses. Here, we first reviewed recent studies on the role of AMPK activation in β-cells. Then, we investigated the expression profile of...

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PMID: 32492936
DOI: 10.3390/ijms21113982
PMCID: PMC7312098

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