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Article

PKA Enhances the Acute Insulin Response Leading to the Restoration of Glucose Control.

Diabetes - 1 May 2015

Kaihara Kelly A, Dickson Lorna M, Ellenbroek Johanne H, Orr Caitlin M D, Layden Brian T, Wicksteed Barton

Abstract excerpt

Diabetes arises from insufficient insulin secretion and failure of the β-cell mass to persist and expand. These deficits can be treated with ligands to Gs-coupled G-protein-coupled receptors that raise β-cell cAMP. Here we studied the therapeutic potential of β-cell cAMP-dependent protein kinase (PKA) activity in restoring glucose control using β-caPKA mice. PKA activity enhanced the acute insulin response (AIR)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25475437
DOI: 10.2337/db14-1051
PMCID: PMC4407848

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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