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Article

miR-204 Targets PERK and Regulates UPR Signaling and β-Cell Apoptosis

6 Jul 2016

Abstract excerpt

Endoplasmic reticulum (ER) stress plays an important role in the pathogenesis of diabetes and the associated β-cell apoptosis. Although microRNAs (miRNAs) have been widely studied in various diseases including diabetes, the role of miRNAs in ER stress and β-cell apoptosis has only started to be elucidated. We recently showed that diabetes increases β-cell miR-204 and have now discovered that miR-204 directly...

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PMID: 27384111
DOI: 10.1210/me.2016-1056

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