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Article

Targeted detection of in vivo endogenous DNA base damage reveals preferential base excision repair in the transcribed strand.

Nucleic acids research - 1 Jan 2012

Reis António M C, Mills Wilbur K, Ramachandran Ilangovan, Friedberg Errol C, Thompson David, Queimado Lurdes

Abstract excerpt

Endogenous DNA damage is removed mainly via base excision repair (BER), however, whether there is preferential strand repair of endogenous DNA damage is still under intense debate. We developed a highly sensitive primer-anchored DNA damage detection assay (PADDA) to map and quantify in vivo endogenous DNA damage. Using PADDA, we documented significantly higher levels of endogenous damage in Saccharomyces...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21911361
DOI: 10.1093/nar/gkr704
PMCID: PMC3245927

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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