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Article

Abasic sites in the transcribed strand of yeast DNA are removed by transcription-coupled nucleotide excision repair.

Molecular and cellular biology - 1 Jul 2010

Kim Nayun, Jinks-Robertson Sue

Abstract excerpt

Abasic (AP) sites are potent blocks to DNA and RNA polymerases, and their repair is essential for maintaining genome integrity. Although AP sites are efficiently dealt with through the base excision repair (BER) pathway, genetic studies suggest that repair also can occur via nucleotide excision repair (NER). The involvement of NER in AP-site removal has been puzzling, however, as this pathway is thought to target...

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Identifiers

PMID: 20421413
DOI: 10.1128/MCB.00308-10
PMCID: PMC2897580

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Source receipt: pubmed, retrieved 7 Sept 2026.

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