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Article

Avoidance of APOBEC3B-induced mutation by error-free lesion bypass.

Nucleic acids research - 19 May 2017

Hoopes James I, Hughes Amber L, Hobson Lauren A, Cortez Luis M, Brown Alexander J, Roberts Steven A

Abstract excerpt

APOBEC cytidine deaminases mutate cancer genomes by converting cytidines into uridines within ssDNA during replication. Although uracil DNA glycosylases limit APOBEC-induced mutation, it is unknown if subsequent base excision repair (BER) steps function on replication-associated ssDNA. Hence, we measured APOBEC3B-induced CAN1 mutation frequencies in yeast deficient in BER endonucleases or DNA damage tolerance...

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Identifiers

PMID: 28334887
DOI: 10.1093/nar/gkx169
PMCID: PMC5605239

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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