Article
Spontaneous mutation, oxidative DNA damage, and the roles of base and nucleotide excision repair in the yeast Saccharomyces cerevisiae.
Yeast (Chichester, England) - 1 Feb 1999
Scott A D, Neishabury M, Jones D H, Reed S H, Boiteux S, Waters R
Abstract excerpt
The OGG1 gene of Saccharomyces cerevisiae encodes a DNA glycosylase that excises 7,8-dihydro-8-oxoguanine (8-OxoG). When compared to wild-type, ogg1 mutants show an increase in the frequency of GC to TA transversions, indicating a role for Ogg1 in the repair of 8-OxoG. Here we report an increased frequency of forward mutation to canavanine resistance in mutants defective in the nucleotide excision repair (NER)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.