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Spontaneous mutagenesis in haploid and diploid Saccharomyces cerevisiae.

Biochemical and biophysical research communications - 17 Dec 2004

Ohnishi Gaku, Endo Kingo, Doi Akiko, Fujita Atsushige, Daigaku Yasukazu, Nunoshiba Tatsuo, Yamamoto Kazuo

Abstract excerpt

To obtain insights into the mechanisms of spontaneous mutations in Saccharomyces cerevisiae, we have characterized the genetic alterations that inactivate either the CAN1 gene in haploid cells or heterozygously situated in diploid cells. The mutation rate in haploid cells was 9.08 x 10(-7), 100-fold lower than that in diploid cells (1.03 x 10(-4)). In haploid cells, among 69 independent CAN1 mutations, 75% were...

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PMID: 15541379
DOI: 10.1016/j.bbrc.2004.10.120

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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