Article

A targeted next generation sequencing approach to develop robust, genotype-specific mutation profiles and uncover novel variants in <i>Saccharomyces cerevisiae</i>

2020-06-27

Abstract excerpt

<h4>ABSTRACT</h4> Distinct mutation signatures arise from environmental exposures and/or from defects in metabolic pathways that promote genome stability. The presence of a particular mutation signature in a cell or a tumor can therefore predict the underlying mechanism of mutagenesis, which, in practice, may be clinically important. These insults to the genome often alter dNTP pools, which itself impacts replica...

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Literature Corpus work: c204c60f-42b4-5e9d-958a-4375bb4b03ec
DOI: 10.1101/2020.06.25.171595

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