Article
αCaMKII autophosphorylation controls exploratory activity to threatening novel stimuli.
Neuropharmacology - 1 Dec 2011
Easton Alanna C, Lucchesi Walter, Schumann Gunter, Giese K Peter, Müller Christian P, Fernandes Cathy
Abstract excerpt
Autophosphorylation of αCaMKII is regarded as a 'molecular memory' for Ca(2+) transients and a crucial mechanism in aversely, but less so in appetitively, motivated learning and memory. While there is a growing body of research implicating αCaMKII in general in behavioral responses to threat or fearful stimuli, little is known about the contribution of the autophosphorylation. The present study asked how αCaMKII...
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