Article
Autophosphorylation of CaMKK2 generates autonomous activity that is disrupted by a T85S mutation linked to anxiety and bipolar disorder.
Scientific reports - 23 Sept 2015
Scott John W, Park Elizabeth, Rodriguiz Ramona M, Oakhill Jonathan S, Issa Samah M A, O'Brien Matthew T, Dite Toby A, Langendorf Christopher G, Wetsel William C, Means Anthony R, Kemp Bruce E
Abstract excerpt
Mutations that reduce expression or give rise to a Thr85Ser (T85S) mutation of Ca(2+)-CaM-dependent protein kinase kinase-2 (CaMKK2) have been implicated in behavioural disorders such as anxiety, bipolar and schizophrenia in humans. Here we report that Thr85 is an autophosphorylation site that endows CaMKK2 with a molecular memory that enables sustained autonomous activation following an initial, transient Ca(2+)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.