Article
αCaMKII autophosphorylation controls the establishment of alcohol drinking behavior.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Aug 2013
Easton Alanna C, Lucchesi Walter, Lourdusamy Anbarasu, Lenz Bernd, Solati Jalal, Golub Yulia, Lewczuk Piotr, Fernandes Cathy, Desrivieres Sylvane, Dawirs Ralph R, Moll Gunther H, Kornhuber Johannes, Frank Josef, Hoffmann Per, Soyka Michael, Kiefer Falk, Schumann Gunter, Peter Giese K, Müller Christian P, Treutlein Jens, Cichon Sven, Ridinger Monika, Mattheisen Peter, Herms Stefan, Wodarz Norbert, Zill Peter, Maier Wolfgang, Mössner Rainald, Gaebel Wolfgang, Dahmen Norbert, Scherbaum Norbert, Schmäl Christine, Steffens Michael, Lucae Susanne, Ising Marcus, Müller-Myhsok Bertram, Nöthen Markus M, Mann Karl, Rietschel Marcella
Abstract excerpt
The α-Ca(2+)/calmodulin-dependent protein kinase II (αCaMKII) is a crucial enzyme controlling plasticity in the brain. The autophosphorylation of αCaMKII works as a 'molecular memory' for a transient calcium activation, thereby accelerating learning. We investigated the role of αCaMKII autophosphorylation in the establishment of alcohol drinking as an addiction-related behavior in mice. We found that alcohol...
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