Article
Autophosphorylation of alphaCaMKII is differentially involved in new learning and unlearning mechanisms of memory extinction.
Learning & memory (Cold Spring Harbor, N.Y.) - 1 Nov 2008
Kimura Ryoichi, Silva Alcino J, Ohno Masuo
Abstract excerpt
Accumulating evidence indicates the key role of alpha-calcium/calmodulin-dependent protein kinase II (alphaCaMKII) in synaptic plasticity and learning, but it remains unclear how this kinase participates in the processing of memory extinction. Here, we investigated the mechanism by which alphaCaMKII may mediate extinction by using heterozygous knock-in mice with a targeted T286A mutation that prevents the...
Topics
- Animals
- Association Learning
- Behavior, Animal
- Calcium-Calmodulin-Dependent Protein Kinase Type 2
- Conditioning, Classical
- Cues
- Extinction, Psychological
- Fear
- Freezing Reaction, Cataleptic
- Maze Learning
- Memory Disorders
- Mice
- Mice, Mutant Strains
- Mutation
- Phosphorylation
- Space Perception