Article
Trace eyeblink conditioning requires the hippocampus but not autophosphorylation of alphaCaMKII in mice.
Learning & memory (Cold Spring Harbor, N.Y.) - 1 Jan 2000
Ohno Masuo, Tseng Wilbur, Silva Alcino J, Disterhoft John F
Abstract excerpt
Little is known about signaling mechanisms underlying temporal associative learning. Here, we show that mice with a targeted point mutation that prevents autophosphorylation of alphaCaMKII (alphaCaMKII(T286A)) learn trace eyeblink conditioning normally. This forms a sharp contrast to the severely impaired spatial learning in the water maze and contextual fear conditioning observed in alphaCaMKII(T286A) mutants....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.