Article
Differential effects of alphaCaMKII mutation on hippocampal learning and changes in intrinsic neuronal excitability.
The European journal of neuroscience - 1 Apr 2006
Ohno Masuo, Sametsky Evgeny A, Silva Alcino J, Disterhoft John F
Abstract excerpt
Alpha-calcium/calmodulin-dependent kinase II (alphaCaMKII) is central to synaptic plasticity but it remains unclear whether this kinase contributes to neuronal excitability changes, which are a cellular correlate of learning. Using knock-in mice with a targeted T286A mutation that prevents the autophosphorylation of alphaCaMKII (alphaCaMKII(T286A)), we studied the role of alphaCaMKII signaling in regulating...
Topics
- Action Potentials
- Alanine
- Analysis of Variance
- Animals
- Behavior, Animal
- Calcium-Calmodulin-Dependent Protein Kinase Kinase
- Electric Stimulation
- Hippocampus
- In Vitro Techniques
- Learning