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Article

Differential effects of alphaCaMKII mutation on hippocampal learning and changes in intrinsic neuronal excitability.

The European journal of neuroscience - 1 Apr 2006

Ohno Masuo, Sametsky Evgeny A, Silva Alcino J, Disterhoft John F

Abstract excerpt

Alpha-calcium/calmodulin-dependent kinase II (alphaCaMKII) is central to synaptic plasticity but it remains unclear whether this kinase contributes to neuronal excitability changes, which are a cellular correlate of learning. Using knock-in mice with a targeted T286A mutation that prevents the autophosphorylation of alphaCaMKII (alphaCaMKII(T286A)), we studied the role of alphaCaMKII signaling in regulating...

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Identifiers

PMID: 16630070
DOI: 10.1111/j.1460-9568.2006.04746.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Differential effects of alphaCaMKII mutation on hippocampal learning and changes in intrinsic neuronal excitability.PMID 16630070Read ↗

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