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Article

Cdkn2a is an atherosclerosis modifier locus that regulates monocyte/macrophage proliferation.

Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 2011

Kuo Chao-Ling, Murphy Andrew J, Sayers Scott, Li Rong, Yvan-Charvet Laurent, Davis Jaeger Z, Krishnamurthy Janakiraman, Liu Yan, Puig Oscar, Sharpless Norman E, Tall Alan R, Welch Carrie L

Abstract excerpt

OBJECTIVE: Common genetic variants in a 58-kb region of chromosome 9p21, near the CDKN2A/CDKN2B tumor suppressor locus, are strongly associated with coronary artery disease. However, the underlying mechanism of action remains unknown. METHODS AND RESULTS: We previously reported a congenic mouse model harboring an atherosclerosis susceptibility locus and the region of homology with the human 9p21 locus. Microarray...

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Identifiers

PMID: 21868699
DOI: 10.1161/ATVBAHA.111.234492
PMCID: PMC3350106

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