Article

Knockout of the Murine Ortholog to the Human 9p21 Coronary Artery Disease Locus Leads to SMC Proliferation, Vascular Calcification, and Advanced Atherosclerosis

2020-01-24

Abstract excerpt

<h4>Background: </h4> Genome-wide association studies have identified the chromosome 9p21 locus as one of the most important genetic risk factors for cardiovascular disease. However, the mechanism by which this locus promotes disease remains unclear due to difficulty identifying the causal genes and lack of a suitable animal model. <h4>Methods and Results:</h4> A total of 180 coronary artery autopsy specimens were...

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Literature Corpus work: dd1135df-9805-59a0-a5fb-62cf9e281897
DOI: 10.20944/preprints202001.0280.v1

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