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Article

Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice.

Nature - 18 Mar 2010

Visel Axel, Zhu Yiwen, May Dalit, Afzal Veena, Gong Elaine, Attanasio Catia, Blow Matthew J, Cohen Jonathan C, Rubin Edward M, Pennacchio Len A

Abstract excerpt

Sequence polymorphisms in a 58-kilobase (kb) interval on chromosome 9p21 confer a markedly increased risk of coronary artery disease (CAD), the leading cause of death worldwide. The variants have a substantial effect on the epidemiology of CAD and other life-threatening vascular conditions becaus...

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Identifiers

PMID: 20173736
DOI: 10.1038/nature08801
PMCID: PMC2938076

Genes

CAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20173736-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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