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Article

Distinct ligand specificity of the Tiam1 and Tiam2 PDZ domains.

Biochemistry - 1 Mar 2011

Shepherd Tyson R, Hard Ryan L, Murray Ann M, Pei Dehua, Fuentes Ernesto J

Abstract excerpt

Guanine nucleotide exchange factor proteins of the Tiam family are activators of the Rho GTPase Rac1 and critical for cell morphology, adhesion, migration, and polarity. These proteins are modular and contain a variety of interaction domains, including a single post-synaptic density-95/discs large/zonula occludens-1 (PDZ) domain. Previous studies suggest that the specificities of the Tiam1 and Tiam2 PDZ domains...

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Identifiers

PMID: 21192692
DOI: 10.1021/bi1013613
PMCID: PMC3059893

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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