Article
The IQGAP-related protein DGAP1 interacts with Rac and is involved in the modulation of the F-actin cytoskeleton and control of cell motility.
Journal of cell science - 1 Oct 1998
Faix J, Clougherty C, Konzok A, Mintert U, Murphy J, Albrecht R, Mühlbauer B, Kuhlmann J
Abstract excerpt
DGAP1 of Dictyostelium discoideum is a cell cortex associated 95 kDa protein that shows homology to both RasGTPase-activating proteins (RasGAPs) and RasGAP-related proteins. When tested for RasGAP activity, recombinant DGAP1 protein did not promote the GTPase activity of human H-Ras or of Dictyos...
Topics
- Actin Cytoskeleton
- Actins
- Amino Acid Sequence
- Animals
- Cell Cycle Proteins
- Cell Movement
- Cell Size
- Dictyostelium
- GTP Phosphohydrolases
- GTP-Binding Proteins
- GTPase-Activating Proteins
- Guanosine Triphosphate
- Humans
- Molecular Sequence Data
- Monomeric GTP-Binding Proteins