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Article

Effects of structure of Rho GTPase-activating protein DLC-1 on cell morphology and migration.

The Journal of biological chemistry - 21 Nov 2008

Kim Tai Young, Healy Kevin D, Der Channing J, Sciaky Noah, Bang Yung-Jue, Juliano Rudy L

Abstract excerpt

DLC-1 encodes a Rho GTPase-activating protein (RhoGAP) and negative regulator of specific Rho family proteins (RhoA-C and Cdc42). DLC-1 is a multi-domain protein, with the RhoGAP catalytic domain flanked by an amino-terminal sterile alpha motif (SAM) and a carboxyl-terminal START domain. The roles of these domains in the regulation of DLC-1 function remain to be determined. We undertook a structure-function...

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Identifiers

PMID: 18786931
DOI: 10.1074/jbc.M800617200
PMCID: PMC2583296

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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