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Article

Adenomatous Polyposis Coli Modulates Actin and Microtubule Cytoskeleton at the Immunological Synapse to Tune CTL Functions.

ImmunoHorizons - 24 Jun 2020

Juzans Marie, Cuche Céline, Rose Thierry, Mastrogiovanni Marta, Bochet Pascal, Di Bartolo Vincenzo, Alcover Andrés

Abstract excerpt

Adenomatous polyposis coli (Apc) is a cell polarity regulator and a tumor suppressor associated with familial adenomatous polyposis and colorectal cancer. Apc involvement in T lymphocyte functions and antitumor immunity remains poorly understood. Investigating Apc-depleted human CD8 T cells and CD8 T cells from ApcMin/+ mutant mice, we found that Apc regulates actin and microtubule cytoskeleton remodeling at the...

Topics

Actins
Adenomatous Polyposis Coli
Adenomatous Polyposis Coli Protein
Animals
Cell Differentiation
Cell Line, Tumor
Cytoskeleton
Female
Gene Expression Regulation, Neoplastic
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunological Synapses

Male

Mice

Mice, Inbred C57BL

Mice, Transgenic

Microtubules

Mutation

NFATC Transcription Factors

Source

Identifiers

PMID: 32581014
DOI: 10.4049/immunohorizons.2000044

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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