Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Proteomic analysis reveals APC-dependent post-translational modifications and identifies a novel regulator of β-catenin.

Development (Cambridge, England) - 15 Jul 2016

Blundon Malachi A, Schlesinger Danielle R, Parthasarathy Amritha, Smith Samantha L, Kolev Hannah M, Vinson David A, Kunttas-Tatli Ezgi, McCartney Brooke M, Minden Jonathan S

Abstract excerpt

Wnt signaling generates patterns in all embryos, from flies to humans, and controls cell fate, proliferation and metabolic homeostasis. Inappropriate Wnt pathway activation results in diseases, including colorectal cancer. The adenomatous polyposis coli (APC) tumor suppressor gene encodes a multifunctional protein that is an essential regulator of Wnt signaling and cytoskeletal organization. Although progress has...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta Catenin
Share to Electrophoresis, Gel, Two-Dimensional

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryo, Nonmammalian

Share to Embryonic Development

Share to Mass Spectrometry

Share to Proteome

Share to Proteomics

Share to Wnt Signaling Pathway

Source

Open in PubMed Open full text

Identifiers

PMID: 27287809
DOI: 10.1242/dev.130567
PMCID: PMC4958330

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Proteomic analysis reveals APC-dependent post-translational modifications and identifies a novel regulator of β-catenin.PMID 27287809Read ↗

The adenomatous polyposis coli protein 30 years on.Semantic proximity Read ↗

Proteomic consequences of a single gene mutation in a colorectal cancer model.Semantic proximity Read ↗

Identification of endogenous Adenomatous polyposis coli interaction partners and β-catenin-independent targets by proteomicsSemantic proximity Read ↗

Comprehensive Proteome Analysis of an Apc Mouse Model Uncovers Proteins Associated with Intestinal TumorigenesisSemantic proximity Read ↗

Testing hypotheses for the functions of APC family proteins using null and truncation alleles in Drosophila.Semantic proximity Read ↗

Adenomatous polyposis coli (APC) plays multiple roles in the intestinal and colorectal epithelia.Semantic proximity Read ↗

One-hit effects in cancer: altered proteome of morphologically normal colon crypts in familial adenomatous polyposis.Semantic proximity Read ↗

Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis.Semantic proximity Read ↗

Interactions and functions of the adenomatous polyposis coli (APC) protein at a glance.Semantic proximity Read ↗

Distinct D-box Motifs in SPD-2 Mediate APC/C <sup>FZR-1</sup> -Dependent Degradation and Centrosomal Localization in <i>Caenorhabditis elegans</i> EmbryosSemantic proximity Read ↗

Dual positive and negative regulation of wingless signaling by adenomatous polyposis coli.Semantic proximity Read ↗

Phenotypic Heterogeneity Analysis of APC-Mutant Colon Cancer by Proteomics and Phosphoproteomics Identifies RAI14 as a Key Prognostic Determinant in East Asians and WesternersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.