Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel mechanism of tumor suppression by polarity gene discs large 1 (DLG1) revealed in a murine model of pediatric B-ALL.

Cancer immunology research - 1 Dec 2013

Sandoval Gabriel J, Graham Daniel B, Gmyrek Grzegorz B, Akilesh Holly M, Fujikawa Keiko, Sammut Benedicte, Bhattacharya Deepta, Srivatsan Shuba, Kim Alfred, Shaw Andrey S, Yang-Iott Katherine, Bassing Craig H, Duncavage Eric, Xavier Ramnik J, Swat Wojciech

Abstract excerpt

Drosophila melanogaster discs large (dlg) is an essential tumor suppressor gene (TSG) controlling epithelial cell growth and polarity of the fly imaginal discs in pupal development. A mammalian ortholog, Dlg1, is involved in embryonic urogenital morphogenesis, postsynaptic densities in neurons, and immune synapses in lymphocytes. However, a potential role for Dlg1 as a mammalian TSG is unknown. Here, we present...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Transformation, Neoplastic
Share to Genes, Tumor Suppressor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasm Transplantation

Share to Phosphatidylinositol 3-Kinase

Share to Precursor B-Cell Lymphoblastic Leukemia-Lymphoma

Share to PTEN Phosphohydrolase

Share to Receptors, Interleukin-7

Share to RNA, Neoplasm

Source

Open in PubMed Open full text

Identifiers

PMID: 24778134
DOI: 10.1158/2326-6066.CIR-13-0065
PMCID: PMC4006353

Genes

PTEN
DLG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel mechanism of tumor suppression by polarity gene discs large 1 (DLG1) revealed in a murine model of pediatric B-ALL.PMID 24778134Read ↗

The Key Roles of PTEN in T-Cell Acute Lymphoblastic Leukemia Development, Progression, and Therapeutic ResponseSemantic proximity Read ↗

Characterization of a Novel Human Cell-Cycle-Regulated Homologue of Drosophila dlg1Semantic proximity Read ↗

Drosophila in cancer research: the first fifty tumor suppressor genes.Semantic proximity Read ↗

Functional nature of a novel mutant CYLD observed in pediatric lymphoblastic B-cell leukemia.Semantic proximity Read ↗

Targeted disruption of the S1P2 sphingosine 1-phosphate receptor gene leads to diffuse large B-cell lymphoma formation.Semantic proximity Read ↗

MicroRNA-497/195 is tumor suppressive and cooperates with CDKN2A/B in pediatric acute lymphoblastic leukemiaSemantic proximity Read ↗

Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia.Semantic proximity Read ↗

Craniofacial dysmorphogenesis including cleft palate in mice with an insertional mutation in the discs large gene.Semantic proximity Read ↗

Developmental regulation of a vertebrate homologue of the Drosophila dlg tumor suppressor gene.Semantic proximity Read ↗

Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer.Semantic proximity Read ↗

Misexpression of cyclin D1 in embryonic germ cells promotes testicular teratoma initiation.Semantic proximity Read ↗

Molecular basis for the recognition of adenomatous polyposis coli by the Discs Large 1 protein.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.