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Article

The tumour suppressor APC promotes HIV-1 assembly via interaction with Gag precursor protein.

Nature communications - 30 Jan 2017

Miyakawa Kei, Nishi Mayuko, Matsunaga Satoko, Okayama Akiko, Anraku Masaki, Kudoh Ayumi, Hirano Hisashi, Kimura Hirokazu, Morikawa Yuko, Yamamoto Naoki, Ono Akira, Ryo Akihide

Abstract excerpt

Diverse cellular proteins and RNAs are tightly regulated in their subcellular localization to exert their local function. Here we report that the tumour suppressor adenomatous polyposis coli protein (APC) directs the localization and assembly of human immunodeficiency virus (HIV)-1 Gag polyprotein at distinct membrane components to enable the efficient production and spread of infectious viral particles. A...

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Share to Acquired Immunodeficiency Syndrome
Share to Adenomatous Polyposis Coli Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to gag Gene Products, Human Immunodeficiency Virus

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Share to RNA, Small Interfering

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Source

Open in PubMed Open full text

Identifiers

PMID: 28134256
DOI: 10.1038/ncomms14259
PMCID: PMC5290283

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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