Article
High-throughput identification of potential minor histocompatibility antigens by MHC tetramer-based screening: feasibility and limitations.
PloS one - 1 Jan 2011
Hombrink Pleun, Hadrup Sine R, Bakker Arne, Kester Michel G D, Falkenburg J H Frederik, von dem Borne Peter A, Schumacher Ton N M, Heemskerk Mirjam H M
Abstract excerpt
T-cell recognition of minor histocompatibility antigens (MiHA) plays an important role in the graft-versus-tumor (GVT) effect of allogeneic stem cell transplantation (allo-SCT). However, the number of MiHA identified to date remains limited, making clinical application of MiHA reactive T-cell infusion difficult. This study represents the first attempt of genome-wide prediction of MiHA, coupled to the isolation of...
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