Article
Peptide-MHC class I and class II tetramers: From flow to mass cytometry.
HLA - 1 Mar 2020
Christophersen Asbjørn
Abstract excerpt
To develop better vaccines and more targeted treatments for cancer and autoimmune disorders, the disease-specific T cells and their cognate antigens need to be better characterized. For more than two decades, peptide-major histocompatibility complex (pMHC) tetramers and flow cytometry have been the gold standard for detection of CD8+ and CD4+ T cells specific to antigens in the context of MHC class I and class...
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