Article

Shared Graft Versus Leukemia Minor Histocompatibility Antigens in DISCOVeRY-BMT

2022-08-15

Abstract excerpt

T cell responses to minor histocompatibility antigens (mHAs) mediate graft versus leukemia (GvL) effects and graft versus host disease (GvHD) in allogeneic hematopoietic cell transplant (alloHCT). Therapies that boost T cell responses improve the efficacy of alloHCT; however, these have been limited by concurrent increases in the incidence and severity of GvHD. mHAs with expression restricted to hematopoietic tiss...

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Literature Corpus work: b66caa63-1fe8-5a8b-bcd6-5b1e15fc4f9c
DOI: 10.1101/2022.08.12.503667

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