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Computational modeling and confirmation of leukemia-associated minor histocompatibility antigens

16 Aug 2018

Abstract excerpt

T-cell responses to minor histocompatibility antigens (mHAs) mediate both antitumor immunity (graft-versus-leukemia [GVL]) and graft-versus-host disease (GVHD) in allogeneic stem cell transplant. Identifying mHAs with high allele frequency, tight binding affinity to common HLA molecules, and narrow tissue restriction could enhance immunotherapy against leukemia. Genotyping and HLA allele data from 101 HLA-matched...

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Share to Advanced biosensing and bioanalysis techniques
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PMID: 30115642
DOI: 10.1182/bloodadvances.2018022475

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