Article
HapMap scanning of novel human minor histocompatibility antigens.
Blood - 21 May 2009
Kamei Michi, Nannya Yasuhito, Torikai Hiroki, Kawase Takakazu, Taura Kenjiro, Inamoto Yoshihiro, Takahashi Taro, Yazaki Makoto, Morishima Satoko, Tsujimura Kunio, Miyamura Koichi, Ito Tetsuya, Togari Hajime, Riddell Stanley R, Kodera Yoshihisa, Morishima Yasuo, Takahashi Toshitada, Kuzushima Kiyotaka, Ogawa Seishi, Akatsuka Yoshiki
Abstract excerpt
Minor histocompatibility antigens (mHags) are molecular targets of allo-immunity associated with hematopoietic stem cell transplantation (HSCT) and involved in graft-versus-host disease, but they also have beneficial antitumor activity. mHags are typically defined by host SNPs that are not shared by the donor and are immunologically recognized by cytotoxic T cells isolated from post-HSCT patients. However, the...
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