Article
In Silico Analysis of the Minor Histocompatibility Antigen Landscape Based on the 1000 Genomes Project.
Frontiers in immunology - 1 Jan 2018
Bykova Nadia A, Malko Dmitry B, Efimov Grigory A
Abstract excerpt
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is routinely used to treat hematopoietic malignancies. The eradication of residual tumor cells during engraftment is mediated by donor cytotoxic T lymphocytes reactive to alloantigens. In a HLA-matched transplantation context, alloantigens are encoded by various polymorphic genes situated outside the HLA locus, also called minor histocompatibility...
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