Article
Degree of predicted minor histocompatibility antigen mismatch correlates with poorer clinical outcomes in nonmyeloablative allogeneic hematopoietic cell transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation - 1 Oct 2010
Larsen Malene Erup, Kornblit Brian, Larsen Mette Voldby, Masmas Tania Nicole, Nielsen Morten, Thiim Martin, Garred Peter, Stryhn Anette, Lund Ole, Buus Soren, Vindelov Lars
Abstract excerpt
In fully HLA-matched allogeneic hematopoietic cell transplantation (HCT), the main mechanism of the beneficial graft-versus-tumor (GVT) effect and of detrimental graft-versus-host disease (GVHD) is believed to be caused by donor cytotoxic T cells directed against disparate recipient minor histocompatibility antigens (miHAs). The most common origin of disparate miHAs is nonsynonymous single nucleotide polymorphism...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.