Article
Refinement of molecular approaches to improve the chance of identification of hematopoietic-restricted minor histocompatibility antigens.
Journal of immunological methods - 1 Jan 2008
de Rijke Björn, van Horssen-Zoetbrood Agnes, Veenbergen Sharon, Fredrix Hanny, de Witte Theo, van de Wiel-van Kemenade Elly, Dolstra Harry
Abstract excerpt
Minor histocompatibility antigens (mHAgs) constitute the target antigens of the T cell-mediated graft-versus-leukemia response after HLA-identical allogeneic stem cell transplantation (SCT). Several human mHAgs have been identified, but only a few are selectively expressed by hematopoietic cells representing potential targets for specific immunotherapy. Molecular approaches including cDNA library screening and...
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