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Article

Family history of Alzheimer disease predicts hippocampal atrophy in healthy middle-aged adults.

Neurology - 29 May 2012

Okonkwo O C, Xu G, Dowling N M, Bendlin B B, Larue A, Hermann B P, Koscik R, Jonaitis E, Rowley H A, Carlsson C M, Asthana S, Sager M A, Johnson S C

Abstract excerpt

OBJECTIVE: To evaluate the longitudinal influence of family history (FH) of Alzheimer disease (AD) and apolipoprotein E ε4 allele (APOE4) on brain atrophy and cognitive decline over 4 years among asymptomatic middle-aged individuals. METHODS: Participants were cognitively healthy adults with (FH+) (n = 60) and without (FH-) (n = 48) a FH of AD (mean age at baseline 54 years) enrolled in the Wisconsin Registry for...

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Identifiers

PMID: 22592366
DOI: 10.1212/WNL.0b013e3182583047
PMCID: PMC3359586

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APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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