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Article

Computationally designed adeno-associated virus (AAV) Rep 78 is efficiently maintained within an adenovirus vector.

Proceedings of the National Academy of Sciences of the United States of America - 23 Aug 2011

Sitaraman Varsha, Hearing Patrick, Ward Charles B, Gnatenko Dmitri V, Wimmer Eckard, Mueller Steffen, Skiena Steven, Bahou Wadie F

Abstract excerpt

Adeno-associated virus (AAV) is a single-stranded parvovirus retaining the unique capacity for site-specific integration into a transcriptionally silent region of the human genome, a characteristic requiring the functional properties of the Rep 78/68 polypeptide in conjunction with AAV terminal repeat integrating elements. Previous strategies designed to assemble these genetic elements into adenoviral (Ad)...

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PMID: 21844368
DOI: 10.1073/pnas.1102883108
PMCID: PMC3161519

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