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Article

Robust AAV Genotyping Based on Genetic Distances in Rep Gene That Are Maintained by Ubiquitous Recombination.

Viruses - 13 May 2022

Beloukhova Marina I, Lukashev Alexander N, Volchkov Pavel Y, Zamyatnin Andrey A, Deviatkin Andrei A

Abstract excerpt

Adeno-associated viruses (AAVs) are a convenient tool for gene therapy delivery. According to the current classification, they are divided into the species AAV A and AAV B within the genus Dependoparvovirus. Historically AAVs were also subdivided on the intraspecies level into 13 serotypes, which differ in tissue tropism and targeted gene delivery capacity. Serotype, however, is not a universal taxonomic...

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PMID: 35632781
DOI: 10.3390/v14051038
PMCID: PMC9143360

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