Identification of a Functionally Relevant Adeno-Associated Virus Rep68 Oligomeric Interface.

doi:10.1128/JVI.00356-16

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Article

Identification of a Functionally Relevant Adeno-Associated Virus Rep68 Oligomeric Interface.

Journal of virology - 1 Aug 2016

Bardelli Martino, Zárate-Pérez Francisco, Agúndez Leticia, Linden R Michael, Escalante Carlos R, Henckaerts Els

Abstract excerpt

UNLABELLED: The life cycle of the human parvovirus adeno-associated virus (AAV) is orchestrated by four Rep proteins. The large Rep proteins, Rep78 and Rep68, are remarkably multifunctional and display a range of biochemical activities, including DNA binding, nicking, and unwinding. Functionally, Rep78 and Rep68 are involved in transcriptional regulation, DNA replication, and genomic integration. Structurally,...

Topics

DNA Replication
DNA, Viral
DNA-Binding Proteins
Humans
Mutagenesis, Site-Directed
Mutation
Protein Binding
Protein Conformation
Protein Multimerization
Viral Proteins

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Identifiers

PMID: 27170758
DOI: 10.1128/JVI.00356-16
PMCID: PMC4944284

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