Article

Adeno-associated virus Type 2 Rep proteins mediate integration of lentiviral vectors

2014-07-04

Abstract excerpt

<h4>Aims: </h4>: Adeno-associated virus type 2 (AAV2) is a naturally defective human parvovirus that is being developed as a gene therapy vector. In dividing cells, AAV2 DNA persists by integration into the host chromosomes. AAV2 is unique among mammalian viruses in its ability to integrate preferentially into a particular locus within human chromosome 19, designated AAVS1 (also known as Mbs 85) . The AAV2 Rep68...

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Literature Corpus work: d5dac943-503b-5333-96d4-f102d665c8f0
DOI: 10.7287/peerj.preprints.326v4

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