Article
Directed adenovirus evolution using engineered mutator viral polymerases.
Nucleic acids research - 1 Mar 2011
Uil Taco G, Vellinga Jort, de Vrij Jeroen, van den Hengel Sanne K, Rabelink Martijn J W E, Cramer Steve J, Eekels Julia J M, Ariyurek Yavuz, van Galen Michiel, Hoeben Rob C
Abstract excerpt
Adenoviruses (Ads) are the most frequently used viruses for oncolytic and gene therapy purposes. Most Ad-based vectors have been generated through rational design. Although this led to significant vector improvements, it is often hampered by an insufficient understanding of Ad's intricate functions and interactions. Here, to evade this issue, we adopted a novel, mutator Ad polymerase-based,...
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