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Characterization of the function of Adenovirus L4 gene products and their impact on AAV vector production

4 Nov 2024

Abstract excerpt

Efficient manufacturing of recombinant adenovirus-associated virus (AAV) vectors is critical to the successful development of genomic medicines. We attempted to optimize AAV vector production in a producer cell line platform. In this system, helper functions required for AAV replication and production are provided via infection with a replication-competent wild-type Adenovirus. To evaluate strategies for the...

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PMID: 39640223
DOI: 10.1016/j.omtm.2024.101370

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