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Article

Biochemical and genetic analysis of the role of the viral polymerase in enterovirus recombination.

Nucleic acids research - 19 Aug 2016

Woodman Andrew, Arnold Jamie J, Cameron Craig E, Evans David J

Abstract excerpt

Genetic recombination in single-strand, positive-sense RNA viruses is a poorly understand mechanism responsible for generating extensive genetic change and novel phenotypes. By moving a critical cis-acting replication element (CRE) from the polyprotein coding region to the 3' non-coding region we have further developed a cell-based assay (the 3'CRE-REP assay) to yield recombinants throughout the non-structural...

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Identifiers

PMID: 27317698
DOI: 10.1093/nar/gkw567
PMCID: PMC5001610

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