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Article

Adeno-associated virus type 2 p5 promoter: a rep-regulated DNA switch element functioning in transcription, replication, and site-specific integration.

Journal of virology - 1 Apr 2007

Murphy Mary, Gomos-Klein Janette, Stankic Marko, Falck-Pedersen Erik

Abstract excerpt

The large Rep proteins, p68 and p78, function as master controllers of the adeno-associated virus type 2 (AAV2) life cycle, involved in transcriptional control, in latency, in rescue, and in viral DNA replication. The p5 promoter may be the nucleic acid complement to the large Rep proteins. It drives expression of the large Rep proteins, it undergoes autoregulation by Rep, it undergoes induction by helper virus,...

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Identifiers

PMID: 17267512
DOI: 10.1128/JVI.02693-06
PMCID: PMC1866101

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