Article
An AP site can protect against the mutagenic potential of 8-oxoG when present within a tandem clustered site in E. coli.
DNA repair - 1 Dec 2007
Cunniffe Siobhan M T, Lomax Martine E, O'Neill Peter
Abstract excerpt
Ionizing radiation induces clustered DNA damaged sites, defined as two or more lesions formed within one or two helical turns of the DNA through passage of a single radiation track. It is now established that clustered DNA damage sites are found in cells and present a challenge to the repair machinery of the cell but to date, most studies have investigated the effects of bi-stranded lesions. A subset of clustered...
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