N-acetoxy-N-acetyl-2-aminofluorene-induced mutagenesis in the lacI gene of Escherichia coli.

doi:10.1093/carcin/11.7.1087

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Article

N-acetoxy-N-acetyl-2-aminofluorene-induced mutagenesis in the lacI gene of Escherichia coli.

Carcinogenesis - 1 Jul 1990

Schaaper R M, Koffel-Schwartz N, Fuchs R P

Abstract excerpt

To study the mechanisms of mutagenesis by the carcinogen N-acetyl-2-aminofluorene (AAF), we determined by DNA sequencing the spectrum of mutations in the Escherichia coli lacI gene induced by the ultimate metabolite N-acetoxy-N-acetyl-2-aminofluorene, using an E. coli derivative with increased pe...

Topics

2-Acetylaminofluorene
Bacterial Proteins
Base Sequence
Chromosome Aberrations
Chromosome Deletion
Escherichia coli
Escherichia coli Proteins
Fluorenes
Lac Repressors
Molecular Sequence Data
Mutation
Repressor Proteins
Transcription Factors

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