Article
PIK3CA kinase domain mutation identifies a subgroup of stage III colon cancer patients with poor prognosis.
Cellular oncology (Dordrecht, Netherlands) - 1 Dec 2011
Fariña Sarasqueta Arantza, Zeestraten Eliane C M, van Wezel Tom, van Lijnschoten Gesina, van Eijk Ronald, Dekker Jan Willem T, Kuppen Peter J K, Goossens-Beumer Ines J, Lemmens Valery E P P, van de Velde Cornelis J H, Rutten Harm J T, Morreau Hans, van den Brule A J C
Abstract excerpt
BACKGROUND: PIK3CA mutations in the helical domain (in exon 9) and in the kinase domain (exon 20) cause tumor formation by different means. We aimed to determine the effects of each of these mutations on survival of colon carcinoma patients. METHODS: A large cohort of 685 colon carcinoma patients was tested for PIK3CA mutations in exons 9 and 20 by single nucleotide primer extension (N = 428) or by real time PCR...
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