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Article

The prevalence of PIK3CA mutations in gastric and colon cancer.

European journal of cancer (Oxford, England : 1990) - 1 Jul 2005

Velho Sérgia, Oliveira Carla, Ferreira Ana, Ferreira António Carlos, Suriano Gianpaolo, Schwartz Simó, Duval Alex, Carneiro Fátima, Machado José Carlos, Hamelin Richard, Seruca Raquel

Abstract excerpt

A wide variety of tumours show PIK3CA mutations leading to increased phosphatidylinositol-3 kinase (PI3K) activity. We have determined the frequency of PIK3CA mutations in exons 9 and 20 that has previously been reported as mutational hotspot regions in distinct tumour models. One hundred and fifty gastrointestinal carcinomas (47 gastric and 103 colorectal) that were characterised for MSI status (76 MSI and 74...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15994075
DOI: 10.1016/j.ejca.2005.04.022

Genes

BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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