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Article

Prognostic role of tumor PIK3CA mutation in colorectal cancer: a systematic review and meta-analysis.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Oct 2016

Mei Z B, Duan C Y, Li C B, Cui L, Ogino S

Abstract excerpt

BACKGROUND: Somatic mutations in the phosphatidylinositol-4,5-bisphosphate 3-kinase/AKT pathway play a vital role in carcinogenesis. Approximately 15%-20% of colorectal cancers (CRCs) harbor activating mutations in PIK3CA, making it one of the most frequently mutated genes in CRC. We thus carried out a systematic review and meta-analysis investigating the prognostic significance of PIK3CA mutations in CRC....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27436848
DOI: 10.1093/annonc/mdw264
PMCID: PMC5035784

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